migradex - 9 in 1 migraine supplement

migradex - 9 in 1 migraine supplement

5897+ Daily
Migradex users
Rated 4.8/5

Formulated by a Pharmacist, migradex is backed by 109 studies to reduce migraine severity and frequencies.*

How does migradex works?

5 unique mechanism of migradex

1) Vascular Muscle Relaxation:
The combination helps regulate vascular tone by reducing levels of nitric oxide, prostaglandins, and histamine in blood vessels, thereby decreasing both the frequency and intensity of migraine attacks.

2) Neuroinflammation Reduction:
Riboflavin and magnesium work synergistically to decrease neuronal inflammation, moderating nerve transmission and reducing attack frequency. This dual-action approach helps maintain neural homeostasis.

3) CGRP Inhibition:
CoQ10 lowers the level of Calcitonin Gene-Related Peptide (CGRP), a key pain signaling protein. This mechanism significantly reduces monthly migraine occurrences.

4) Homocysteine Regulation:
Elevated homocysteine levels, often associated with MTHFR gene mutations, are a significant migraine trigger. Vitamin B6 and folate facilitate homocysteine metabolism, helping to prevent attacks through improved methylation.

5) Mitochondrial Support:
Migraines are frequently linked to mitochondrial dysfunction caused by nutritional deficiencies. This comprehensive formula addresses these deficits by providing essential vitamins and magnesium, supporting optimal mitochondrial function.

How Long it takes to see effect

Migradex starts working within 2-3 weeks. Since every individual is different, it might take 4-12 weeks to see the full effect*

Can i take migradex with other prescription medications?

Absolutely! Migradex is a natural formulation that can be taken with other prescription medications.

Do I need 400–600mg of magnesium?

Not at all. That number comes from confusion between compound weight and the elemental magnesium your body actually uses. Clinical trials show success at much lower doses ( 30mg- 100mg). Migradex provides 200mg of elemental magnesium in a bisglycinate/oxide complex—an effective amount that’s gentle on the stomach. Plus, it’s paired with vitamin D and B6, which enhance magnesium’s benefits for even better migraine support.

Do I need 400mg of Riboflavin?

Your body can only absorb about 200mg per day, so most of a 400mg dose is wasted. Studies show lower amounts can work just as well. Migradex provides 250mg of riboflavin, the optimized dose-plus magnesium, vitamin D, and B6-to deliver real migraine support without the excess.

Ingredients


Ships from Michigan

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  • files/Screenshot_2024-12-03_at_12.03.00_AM.webp

    Trying migradex was the best decision of my life. After 30 years of migraines, I went from 14 attacks a month to just 2 !

    Sarah H.
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    Migradex is the only thing that works for me. i am down from 12 migraine a month to just 2 !

    Mike, S
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    migradex Ingredients Praised

    Less migraines, More you

    • Fewer migraines

    • All Day Energy

    • Reduced Stress

    • No Brain Fog

    • Better Sleep

    • Productivity

      Less migraines, More you

      Less Migraines

      Reduced Stress

      Productivity

      All Day Energy

      No Brain Fog

      Better Sleep

      Customer Reviews

      Based on 106 reviews
      76%
      (81)
      23%
      (24)
      1%
      (1)
      0%
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      0%
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      L
      Leslie Meskin
      Lessens the pain

      After several months, I see an improvement in the pain level. The frequency seems about the same but the pain is less intense.

      A
      Adriana
      Just started the treatment and already feeling

      Just started the treatment and already feeling positive results!

      D
      Dena Bitel
      On my second month

      On my second month and believe I am feeling better. I typically start my day in one type of a headache or another, and then first 45 days I have only had 3 migraines verses the typical every three day migraines that seem to last 2 or 3 days at a time. So improvement for sure. I know it takes time to reallysee total improvement

      A
      Anonymous
      Great product

      I’ve been using these for 3-4 months and they seem to be helping, by supporting my prescription meds. It’s a convenient way to get all of the “recommended” supplements for those of us suffering from migraine. I also have celiac and must adhere to a gluten free diet and I have not had any issues with them.

      j
      james
      It worked ok got a couple headaches but my issues were my stomach even when I ate something so

      It worked ok got a couple headaches but my issues were my stomach even when I ate something so.I stopped taking it

      123

      Its not magic, Its Science

      Each Ingredient is accurately dosed by pharmacist referencing more than 109 human studies to provide maximum efficacy.

      Magnesium (bisglycinate)

      Riboflavin

      Coenzyme Q10

      Thiamine

      Feverfew

      Vitamin B6 + B12

      Vitamin D3

      Methyl Folate

      Magnesium (bisglycinate)

      Over 60% Americans have magnesium deficiency. This essential mineral helps relax blood vessels, reducing the chance of migraine attacks. It's also known to ease stress, a common migraine trigger, making it essential in migraine management.*

      Riboflavin

      Also known as Vitamin B2, is great at reducing sensitivity to light, a major migraine trigger. By reducing light sensitivity, it can lower how often migraines happen and how bad they feel.*

      Coenzyme Q10

      CoQ10 increases cellular energy production and regulates serotonin and dopamine levels in the brain. These neurotransmitters improves mood and pain perception, making CoQ10 effective in reducing both frequency and severity.*

      Thiamine

      Thiamine helps with energy metabolism, ensuring optimal brain cell function. It reduces frequency and severity of by resisting triggers.*

      Feverfew

      Used for centuries, this herb stabilizes mood and helps with migraines by inhibiting inflammatory histamines. It promotes overall brain health, relaxes tension, and improves blood flow.*

      Vitamin B6 + B12

      Vitamin B6 + B12 increases metabolism of homocysteine. homocysteine is directly linked to migraine attacks. It also reduces stress and blood vessel inflammation.*

      Vitamin D3

      81.6% migraine patients in clinical study had low vitamin D. By promoting healthy sleep and mood, it reduces migraine risk, as disrupted sleep and mood disturbances are common triggers. Vitamin D may also lower the risk of autoimmune reactions contributing to migraines.*

      Methyl Folate

      Folic acid plays major role in mitochondria energy generation. It also increases breakdown of homecysteine. It reduces frequency and severity.*

      See how migradex changes lives in just 6 weeks

      92%

      Experienced better overall quality of life¹*

      85%

      Noticed that migradex has significantly reduces number of migraine attacks by 70 %.¹*

      76%

      Noticed that migradex reduces migraine symptoms by 72%.¹*

      ¹ based on migradex's ingredients human studies

      Before

      After

       
       

      From Daily Pain to Daily Life — Real People. Real Relief

      •  

        From 20 migraines/month to 5 !

      •  

        Every migraine sufferer should take migradex!

      •  

        My family thanks migradex everyday

        FAQ

        Is migradex Safe?

        Yes, migradex is made with all natural ingredients that are generally considered safe when taken as directed. However, it is important to consult with your healthcare provider before starting any new supplement, especially if you have underlying health conditions or are taking other medications such as warfarin (coumadin)*

        Who should not take migradex?

        migradex should not be used by children less than 18 years of age and pregnant and breastfeeding mothers.*

        No Butterbur?

        Many clinical trials suggest that butterbur is very effective in reducing migraine attacks. However, the American Headache Society no longer recommends the use of butterbur as it contains pyrrolizidine alkaloids (PAs), which can cause liver damage. We tested seven different PA-free extracts and found that all of them contained trace amounts of PAs. Since safety is our first priority, we decided not to include butterbur in our formulation.*

        Urine color change?

        The change in urine color is due to riboflavin (vitamin B2). Excess riboflavin is excreted via urine, which can change its color to bright yellow or orange. This color change is completely harmless and indicates that your body is utilizing the vitamins effectively.*

        How migradex compares to prescription medications

        There are very few prescription options available for preventing migraines, and most of them have undesirable side effects. Being a natural formulation, Migradex doesn't have side effects and works just as well, if not better. Additionally, Migradex targets root causes like nutritional deficiencies and homocysteine metabolism that prescription medications doesn't.*

        Clinical References

        Riboflavin (Vitamin B2)

        1. Experimental and Clinical Evidence of the Effectiveness of Riboflavin on Migraines. Nutrients2021, 13, 2612. LINK
        2. Riboflavin: The Health Benefits of a Forgotten Natural Vitamin. Int. J. Mol. Sci. 2020, 21, 950 LINK
        3. Effect of riboflavin status on the homocysteine lowering effect of folate in relation to the MTHFR (C677T) genotype. Clin. Chem. 2003, 49, 295–302. LINK
        4. Oral riboflavin in migraine prophylaxis: An open label randomized controlled trial. Neurol. Asia 2011, 16, 223–229. LINK
        5. Riboflavin as a photosensitizer. Effects on human health and food quality. Food Funct. 2012, 3, 487–502. LINK
        6. Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey. LINK
        7. Boehnke, C., et al. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol, 2004. PMID: 15272863
        8. Schoenen, J., et al. Effectiveness of high-dose riboflavin in migraine prophylaxis. Neurology, 1998. PMID: 9484373

        Coenzyme Q10

        1. Sandor, P. S., et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology, 2005. PMID: 15728297
        2. Hershey, A. D., et al. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache, 2007. PMID: 17305328

        Feverfew

        1. Johnson, E. S., et al. Efficacy of feverfew as prophylactic treatment of migraine. BMJ, 1985. PMID: 3927985
        2. Murphy, J. J., et al. Randomised double-blind placebo-controlled trial of feverfew in migraine prevention. Lancet, 1988. PMID: 2899772

        Vitamin D

        1. Zandifar, A., et al. Vitamin D status in migraine patients: a case-control study. Biomed Res Int, 2014. PMID: 24729938
        2. Gazerani, P., et al. A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D3 supplementation in adult patients with migraine. Curr Med Res Opin, 2019. PMID: 30588823

        Vitamin B1 (Thiamine)

        1. Altura, B. M., & Altura, B. T. Magnesium, thiamine and vascular tone and reactivity: relationship to migraine. Magnesium, 1982. PMID: 6761562

        Vitamin B6

        1. Menon, S., et al. The role of MTHFR gene variants in migraine. Mol Genet Metab, 2011. PMID: 21546185
        2. Peikert, A., et al. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia, 1996. PMID: 8823975

        Folic Acid

        1. Frosst, P., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet, 1995. PMID: 7647779
        2. Lea, R., et al. The use of vitamin supplements in the treatment of migraine. Med Hypotheses, 2004. PMID: 15288371

        Magnesium

        1. Mauskop, A., & Altura, B. T. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci, 1998. PMID: 9533522
        2. Ramadan, N. M., et al. Low brain magnesium in migraine. Headache, 1989. PMID: 2618945